GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs1873494 | chr7:65649899 | CCT6P1 | chr7:65216092-65228661:+ | -0.67 | -5.68 | 1.48E-7 | Diabetic kidney disease |
| THYM | cis | rs10935120 | 1 | rs1874883 | chr3:134205071 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.04 | 2.51E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1874883 | chr3:134205071 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.88 | 6.17E-8 | Height |
| THYM | cis | rs703842 | 1 | rs1875124 | chr12:58196802 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.72 | 1.22E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs1875124 | chr12:58196802 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.12 | 1.6E-6 | Multiple sclerosis |
| THYM | cis | rs1875620 | 1 | rs1875620 | chr9:91540059 | C9orf47 | chr9:91605778-91611055:+ | 0.29 | 4.92 | 3.69E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs7223966 | 1 | rs1877316 | chr17:61766880 | TCAM1P | chr17:61934376-61941738:+ | -0.52 | -4.17 | 6.75E-5 | Body mass index |
| THYM | cis | rs10935120 | 1 | rs1880376 | chr3:134270347 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1880376 | chr3:134270347 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs10935120 | 1 | rs1880377 | chr3:134270468 | ANAPC13 | chr3:134196547-134204865:- | -0.59 | -8.13 | 1.58E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs1880377 | chr3:134270468 | CEP63 | chr3:134204575-134293852:+ | -0.41 | -5.87 | 6.33E-8 | Height |
| THYM | cis | rs9309473 | 1 | rs1881245 | chr2:73649928 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 4.75 | 7.32E-6 | Metabolite levels |
| THYM | cis | rs2463822 | 1 | rs1881534 | chr11:62085083 | ASRGL1 | chr11:62104774-62160885:+ | 0.55 | 5.3 | 7.38E-7 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs4974559 | 1 | rs1882099 | chr4:1352685 | CRIPAK | chr4:1385340-1389782:+ | 0.76 | 6.47 | 4.27E-9 | Systolic blood pressure |
| THYM | cis | rs1499614 | 1 | rs1882655 | chr7:66147057 | CCT6P1 | chr7:65216092-65228661:+ | -0.59 | -4.86 | 4.58E-6 | Gout |